Why Your Supplements Might Not Be Working

Are You Taking the Wrong Supplements? Theo Wiley on Genetics, Creatine and Personalised Nutrition

Most people choose supplements by guesswork.

They walk into a shop, pick something off the shelf, follow the same dosage as everyone else, and hope it works. But if two people have different bodies, diets, training demands, genetics, and recovery needs, why would the same supplement plan work equally well for both?

In this episode, Dr Martin Jones speaks with Theo Wiley, founder of Myoform, about the science of personalised supplementation and why the future of performance, recovery and health may be far more individualised than the current supplement industry suggests.

Theo explains how genetics, biomarkers, wearables, lifestyle data and testing could change the way we approach nutrition. He also breaks down which supplements have the strongest evidence, where people waste money, and why quality control in the supplement industry matters more than most consumers realise.

This conversation is for athletes, coaches, leaders and anyone who wants to make better decisions about supplements, recovery, energy, health and long-term performance.

In this episode, you’ll learn

Why the same supplement can produce different results in different people

How genetics may influence nutrient needs, recovery and performance

Why one-size-fits-all supplement advice is often flawed

Which supplements have the strongest evidence behind them

How biomarkers, wearables and genetic testing could personalise health decisions

Why placebo effects can still influence performance

The risks of contamination and poor quality control in supplements

What personalised health could look like over the next five years

Why creatine, vitamin D, omega-3 and protein remain key evidence-based options

Theo Wiley is a scientist, entrepreneur, and founder building at the intersection of genomics and human performance. With a background in human biosciences, he’s spent a decade in biotech and gene therapies, working across neurodegenerative disorders and rare diseases. Now, as the co-founder and CEO of Myoform, he applies the principles of precision medicine to health and performance. Myoform is an AI-driven platform that combines whole-genome sequencing, blood biomarkers, wearable data, and lifestyle inputs to generate personalised supplement formulations that update over time based on an individual’s biology. Based in London and operating across the UK and the US, he leads a team that turns cutting-edge science into everyday health decisions. Today, Theo is focused on proving that nutrition tailored to a person’s biology can optimise how they train, recover, and live.

LinkedIn: https://www.linkedin.com/in/theo-wiley-877457103/

Instagram: https://www.instagram.com/theo.wiley_/

Myoform: https://myoform.io/

Research resource mentioned: https://examine.com/

00:11 Do Supplements Work?

02:18 Creatine And Genetics

04:15 Four Keys To Results

05:45 Founding Myoform

07:35 Why Personalisation Matters

10:04 The Microbiome

12:45 How Myoform Works

15:24 Genomics And Risk Scores

19:15 Magnesium And Placebo

21:31 Using Wearables

26:23 Traits And Injury Risk

29:34 Nootropics And Brain Boosts

35:58 Quality Control And Safety

38:34 Budget Personalisation Basics

42:15 Future Of Health Data

45:32 Closing Thoughts And Links